Research in the Gomperts laboratory is focused on the study of Dementia with Lewy Bodies, Alzheimer’s, and Parkinson’s, dissected through a vertically organized program that extends from bench to bedside.
Dr. Gomperts’s basic and clinical research focuses on Parkinson’s disease, dementia with Lewy bodies, and Alzheimer’s disease. In human studies, he is working to understand the causes of cognitive impairment that can arise in these diseases with PET imaging of pathogenic processes, such as the accumulation of beta-amyloid and tau and the loss of dopamine neurons projecting to brain regions that subserve cognition. In animal models, he uses large scale, multi-electrode recordings of brain cell activity together with optogenetic tools to investigate normal brain function and develop treatments to restore brain function in these diseases.
Stephen Gomperts, MD, PhD is Associate Professor of Neurology at Harvard Medical School and attending physician at Massachusetts General Hospital. He is the Founding Director of the MGH Lewy Body Dementia Unit.
Selected Publications
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Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease.
Zhou H, Li H, Gowravaram N, Quan M, Kausar N, Gomperts SN.
Sci Rep. 2022 Dec 5;12(1):21022. doi: 10.1038/s41598-022-25364-2.
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Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.
Shirvan J, Clement N, Ye R, Katz S, Schultz A, Johnson KA, Gomez-Isla T, Frosch M, Growdon JH, Gomperts SN.
Neurology. 2019 Jul 30;93(5):e476-e484. doi: 10.1212/WNL.0000000000007855. Epub 2019 Jun 26.
Zhou H, Li H, Gowravaram N, Quan M, Kausar N, Gomperts SN.
Sci Rep. 2022 Dec 5;12(1):21022. doi: 10.1038/s41598-022-25364-2.
Shirvan J, Clement N, Ye R, Katz S, Schultz A, Johnson KA, Gomez-Isla T, Frosch M, Growdon JH, Gomperts SN.
Neurology. 2019 Jul 30;93(5):e476-e484. doi: 10.1212/WNL.0000000000007855. Epub 2019 Jun 26.